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Chronic acquired lymphedema

MedGen UID:
78533
Concept ID:
C0265191
Disease or Syndrome
Synonyms: Secondary Lymphedema; Secondary lymphedema
SNOMED CT: Chronic acquired lymphedema (28590005); Secondary lymphedema (28590005)

Definition

A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic acquired lymphedema

Professional guidelines

PubMed

Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641

Recent clinical studies

Etiology

Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article
Wollina U
Dermatol Ther 2019 Mar;32(2):e12805. Epub 2018 Dec 27 doi: 10.1111/dth.12805. PMID: 30565362

Diagnosis

Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Brouillard P, Witte MH, Erickson RP, Damstra RJ, Becker C, Quéré I, Vikkula M
Nat Rev Dis Primers 2021 Oct 21;7(1):77. doi: 10.1038/s41572-021-00309-7. PMID: 34675250
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article
Grada AA, Phillips TJ
J Am Acad Dermatol 2017 Dec;77(6):1009-1020. doi: 10.1016/j.jaad.2017.03.022. PMID: 29132848
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641

Therapy

Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Torgbenu E, Luckett T, Buhagiar MA, Phillips JL
Adv Wound Care (New Rochelle) 2023 Jan;12(1):15-27. Epub 2022 Apr 6 doi: 10.1089/wound.2021.0149. PMID: 35196892
de Sire A, Losco L, Lippi L, Spadoni D, Kaciulyte J, Sert G, Ciamarra P, Marcasciano M, Cuomo R, Bolletta A, Invernizzi M, Cigna E
Medicina (Kaunas) 2022 Jul 19;58(7) doi: 10.3390/medicina58070954. PMID: 35888673Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article

Prognosis

Bonetti G, Dhuli K, Michelini S, Michelini S, Michelini S, Ricci M, Cestari M, Bertelli M
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E200-E205. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2761. PMID: 36479479Free PMC Article
Brouillard P, Witte MH, Erickson RP, Damstra RJ, Becker C, Quéré I, Vikkula M
Nat Rev Dis Primers 2021 Oct 21;7(1):77. doi: 10.1038/s41572-021-00309-7. PMID: 34675250
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Keo HH, Gretener SB, Staub D
Vasa 2017 Jul;46(4):255-261. Epub 2017 Mar 10 doi: 10.1024/0301-1526/a000622. PMID: 28281399
Budd GT
Curr Oncol Rep 2002 Nov;4(6):515-9. doi: 10.1007/s11912-002-0066-3. PMID: 12354365

Clinical prediction guides

Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Lurie F, Malgor RD, Carman T, Dean SM, Iafrati MD, Khilnani NM, Labropoulos N, Maldonado TS, Mortimer P, O'Donnell TF Jr, Raffetto JD, Rockson SG, Gasparis AP
Phlebology 2022 May;37(4):252-266. Epub 2022 Mar 8 doi: 10.1177/02683555211053532. PMID: 35258350Free PMC Article
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Urbanek T, Juśko M, Kuczmik WB
ESC Heart Fail 2020 Oct;7(5):2012-2020. Epub 2020 Jul 25 doi: 10.1002/ehf2.12848. PMID: 32710511Free PMC Article
Keo HH, Gretener SB, Staub D
Vasa 2017 Jul;46(4):255-261. Epub 2017 Mar 10 doi: 10.1024/0301-1526/a000622. PMID: 28281399

Recent systematic reviews

Drobot D, Leitner Shemy O, Zeltzer AA
J Vasc Surg Venous Lymphat Disord 2024 Jan;12(1):101676. Epub 2023 Sep 9 doi: 10.1016/j.jvsv.2023.08.015. PMID: 37696416Free PMC Article
Torgbenu E, Luckett T, Buhagiar MA, Phillips JL
Adv Wound Care (New Rochelle) 2023 Jan;12(1):15-27. Epub 2022 Apr 6 doi: 10.1089/wound.2021.0149. PMID: 35196892
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Walker J, Tanna S, Roake J, Lyons O
J Vasc Surg Venous Lymphat Disord 2022 Jul;10(4):966-975.e1. Epub 2021 Sep 26 doi: 10.1016/j.jvsv.2021.09.004. PMID: 34587525
Beelen LM, van Dishoeck AM, Tsangaris E, Coriddi M, Dayan JH, Pusic AL, Klassen A, Vasilic D
Ann Surg Oncol 2021 Mar;28(3):1656-1668. Epub 2020 Nov 28 doi: 10.1245/s10434-020-09346-0. PMID: 33249519Free PMC Article

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